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The NAPE synthesized by this bacterium can compensate for the reduced intestinal biosynthesis of NAPEs due to the chronic patient's high-fat diet, and this compensatory effect was demonstrated in mouse models to partially restore NAE levels in mouse tissues and significantly reduce key markers of cardiometabolic diseases, such as hepatic steatosis, inflammation, and necrotic atherosclerotic plaque formation in these mice (22)

Infertility, defined as a couples inability to conceive after one year of regular unprotected intercourse, is a significant health issue impacting 50-80 million individuals worldwide (3638)

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