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LDN temporarily blockades the opioid receptors in the brain When the receptors are blocked, the body thinks more opioids are needed, and so it produces more

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Long-standing baseline cognitive deficits reduced cognitive reserve, cumulative antipsychotic exposure, and histories of institutionalization may lower the threshold for meeting clinical dementia criteria during normative aging, even in the absence of primary neurodegenerative pathology (2, 23, 24)