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Its not uncommon to notice a mild increase in discomfort or a short flare reaction within the first day or two, but this is usually temporary and resolves on its own

Injection site reactions redness, swelling, or itching at the subcutaneous injection site

This study demonstrated that GES had potential to influence CNS control mechanisms related to nausea and vomiting via activation of vagal afferent pathway, and then increased vagal efferent tone to mitigate gastric sensitivity, all of which ameliorated postprandial gastric accommodation

Animal data: strong In obese mouse models, AOD-9604 consistently reduced body weight and increased fat oxidation over 14 days of treatment