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Vitamin B12 is a co-factor in the transfer of methyl groups in the body, important in the synthesis of DNA

Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer

Adjusting application frequency or switching products often resolves this

This involves the use of radionuclides emitting particles, like 225 Ac, 212 Pb or 211 At, and -particles like 90 Y, 131 I, or 177 Lu, to exert cytotoxic effects