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The response rates were higher for cyclosporine A and methotrexate in second-line treatment than in first-line treatment (57.3% vs 68.8% and 29.1% vs 62.7%, respectively) whereas the higher response rates for cyclophosphamide was in first-line treatment (68.2% vs 57.4%)

Conversely, treatment with free DOX resulted in significant cell death in normal organs, particularly the heart, while the toxicity of DOX/LAAM GSH-CQDs was minimal (Supplementary Fig

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