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In addition, it required normal renal function and complete urine collection

Erastin triggers ferroptosis in colorectal cancer cells by activating the PERK-NRF2-HO-1 signaling pathway, thereby exerting potent anti-tumor effects ( 3 Ferroptosis and NAFLD 3.1 Ferroptosis and inflammation Globally, the prevalence of NAFLD continues to rise, encompassing a spectrum of conditions from simple steatosis to NASH, fibrosis, and cirrhosis ( In vitro , BMP2 overexpression reduced oxidative stress markers, including ROS and malondialdehyde (MDA), alleviating ferroptosis and attenuating liver inflammation ( 3.2 Ferroptosis and lipid metabolism Ferroptosis, a recently discovered form of regulated cell death characterized by iron-dependent lipid peroxidation, has emerged as a major focus in biological research due to its implications in various diseases

Specifically, EGF blocks the upregulation of NOX4 expression in a phosphoinositide 3-kinase (PI3K)-dependent manner