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Tumour microenvironment (TME)-targeted nanotherapy Reprogramming the TME is a critical direction in nanotherapy, with strategies including immune cell regulation and metabolic intervention

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*Correspondence: Oliver Werz, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany

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The comet assay in association with gamma-H2AX foci showed DNA injury, and the overexpression of Bax and PARP1 cleavage showed cellular apoptosis after the combination treatment

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However, this process may also propagate disease to other brain regions when the pathogenic protein (for example, synuclein, tau) is endocytosed and delivered to lysosomes of unaffected neurons 319

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