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doi:10.2337/diacare.24.4.683

8k), leading to synergistic reduction of intratumoral GSH levels and improved animal survival (Fig

Preclinical studies and clinical trials suggest that antioxidants, such as small thiol molecules (N-acetyl-L-cysteine and carbocysteine), antioxidant enzymes (glutathione peroxidases), activators of Nrf2-regulated antioxidant defense system (sulforaphane), and vitamins, for example, C, E, and D, enhance the endogenous antioxidant system and reduce oxidative stress

Under normal conditions approximately 90% of glucose flows through glycolysis, with a much smaller fraction being channeled through the HMP pathway