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Brostallicin sensitivity for brostallicin is higher in cells overexpressing either the GST-pi or the GST-mu gene 4-[3-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-3-hydroxybutoxy]-7H-furo[3,2-g]chromen-7-one - a furocoumarin from Dorstenia elliptica, 34% total inhibition at 0.033 mM 5,7-dihydroxy-6-(2-hydroxybutanoyl)-8-(3-methylbut-2-en-1-yl)-4-propyl-2H-chromen-2-one - a coumarin from Mammea africana, 33% total inhibition at 0.033 mM 5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione - an isofuranonaphthoquinone from Bulbine frutescens, the mode of inhibition is mixed, partial (G site) and noncompetitive (H site), 68% total inhibition at 0.033 mM 5-(chloromethyl)-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-3',6'-diyl diacetate i.e

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Biol Chem 289: 23200-23208 (2014)

Astrocytes are star-shaped glial cells critical for neuronal support, ionic homeostasis, neuroprotection, and synaptic regulation [127]