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Description

This cumulative risk effect is particularly pronounced in the cardiovascular domain

Metformin enhances autophagy and provides cardioprotection in delta-sarcoglycan deficiency-induced dilated cardiomyopathy

10.1038/s41374-022-00737-3 77 XuS.WuB.ZhongB.LinL.DingY.JinX.et al (2021)

Importantly, low Se levels in pregnant women affect fetal growth and augment the risk of delivering a small-for-gestational age infant by reducing placental antioxidant defense, while low Se in the third trimester is thought to indicate increased demands by the placenta, an issue which requires further confirmation