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In vivo , Bin-4 significantly reduces blood glucose and increases insulin and GLP-1 levels through this synergistic mechanism, providing a theoretical basis for the design of gas signaling molecule-based anti-diabetic drugs ( 7.2 The impact on fat metabolism Recent experiments have found that silybin directly downregulates the expression of key pro-inflammatory factors (such as TNF- and IL-1) by inhibiting the NF-B pathway, thereby reducing macrophage recruitment and inflammation mediator production in adipose tissue, and helping to restore the expression of the anti-inflammatory adipokine adiponectin

Consistently, tracing of the metabolic fate of BCAAs suggested that BCAAs are not a major carbon source for the production of TCA intermediates in brown adipocytes [70,71]

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doi: 10.1046/j.1365-2141.2001.02661.x 9 KudvaGCMaliekelKRichartJMBatanianJRGrossoLESokol-AndersonMet al