While genetic association studies for common variants in the GDNF gene have been underpowered for tinnitus, plasma biomarker studies have identified GDNF among top circulating proteins associated with constant tinnitus, though these associations did not survive strict multiple testing corrections (Amanat et al., 2021
Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe plaque psoriasis over 52 weeks: a phase III, randomized, controlled trial (ESTEEM 2)
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Although these drugs are effective in improving cognitive function and daily living abilities, they have limited efficacy in diabetic cognitive dysfunction, and available data suggest that antidiabetic drugs have the potential to improve cognitive dysfunction and dementia (9)
