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In this same pathway of sulfur amino acids, HCY can be metabolized producing glutathione (GSH) ( Figure 1 ) ( IL1B and CCL3 also play a central role in the pathophysiology of COVID-19 ( Figure 1 The hypothesis of this study is that, during the advanced phase of COVID-19, characterized by hyperinflammation (cytokine storm), supplemental vitamin B12 would increase the flow of the sulfur amino acid pathway, favoring the production of SAM and the antioxidant GSH

In bipolar disorder, manic, hypomanic, and depressive episodes usually persist for days to weeks, sometimes longer, and create a sustained shift from a persons baseline