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In vivo studies of AML xenografted mice showed that the ADC significantly depleted bone marrow HSPCs and peripheral blood myeloid cells, leading to ADC-treated mice showing an extended survival versus untreated and isotype control

Sodium Retention : Certain inflammatory pathways can increase sodium retention in the kidneys, expanding blood volume and raising pressure

KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS 6.1 Absorption 6.2 Distribution 6.2.1 Animal studies 6.2.1.1 Distribution after inhalation exposure 6.2.1.2 Distribution to the embryo and fetus 6.2.1.3 Distribution to the brain 6.2.2 Human studies 6.3 Metabolism 6.3.1 Animal studies 6.3.1.1 Liver 6.3.1.2 Respiratory tract 6.3.1.3 Kidneys 6.3.1.4 Testes and ovaries 6.3.1.5 Embryonic tissue 6.3.1.6 Metabolism during pregnancy 6.3.2 Human studies 6.4 Elimination 6.5 Reaction with cellular macromolecules 6.5.1 Proteins 6.5.2 Nucleic acids 7

Oral glutathione has poor absorptiontypically only 5-10% reaches systemic circulation due to breakdown in the digestive tract