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Hensley K, Benaksas EJ, Bolli R, Comp P, Grammas P, Hamdheydari L et al

For example, mTORi-HDL suppress trained immunity in myeloid cells and promote the expansion of anti-inflammatory Ly6C - macrophages, alleviating graft rejection and prolonging graft survival (214)

Under oxidative stress, cells increase the expression of GSTA1 and GSTA4 , helping to scavenge free radicals and other harmful oxidants, thereby protecting testicular tissue from damage, and increasing the cell viability 53

Therefore, the success of future research depends not only on in depth exploration of molecular mechanisms, but also on whether advanced drug delivery technologies (such as nano targeted drug delivery) and rational clinical design can cleverly utilize its mechanism of action while minimizing off target side effects