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The pro-oncogenic action of PLAG1 was mainly mediated by the IGF2 signaling pathway (114), and IGF2 expression was markedly reduced by miR-181a, miR-135a and miR-302c overexpression (102)

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Additionally, alanine is reported to be significantly increased with metformin monotherapy and combined with sulfonylurea, and branched-chain amino acids (valine, leucine, and isoleucine) are increased with metformin therapy (t Hart et al., 2018b)

Thirty-five male mice were divided into seven groups, each subjected to various mobile phone modes and glutathione treatments