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AlphaFold predictions of NS3h, RNA and NS5B suggest possible roles for D1467 in initiation of () strand synthesis In view of NS3 binding to (+) 5BSL3 and () SL (the counterpart of 3X SL1) and of the reduced NS3 and NS5B interaction, we next aimed to model atomic structures of complexes of NS3 with NS5B and, by taking advantage of the newly available Alphafold3 (AF3) 67 , with viral RNA

Hayes JD, McMahon M

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