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In recent work, Lopes and colleagues demonstrated that caffeine increased the energy charge and redox state of cortical synaptosomes, suggesting that this effect led to an increase in the glycolytic rate, thereby enhancing astrocyte-synapse lactate transport

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Riboflavin deficiency is prevalent in many regions over the world, particularly in underdeveloped countries with a low intake of dairy products and meats 5,6,7,8