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The premise underlying the leaky gut hypothesis is that physiologic stressors such as anxiety, intensive exercise, or dietary components such as emulsifiers increase intestinal mucosal paracellular permeability, enhancing entry of pathogenic bacteria and bacterial toxins into the systemic circulation, provoking systemic inflammation and triggering numerous diseases

Animal studies show oral and drinking-water routes preserve activity, attributed to the unusual gastric-juice stability

Individuals with asthma, particularly those with neutrophilic asthma, exhibited the presence of NLRP3 (209)