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Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB

Through analyzing tumor-specific metabolic divergence from normal cellular processes, we map actionable intervention pathways for CRC prevention and treatment, while advancing conceptual understanding of its pathobiological complexity

Nat Rev Gastroenterol Hepatol (2020) 17:687701

Aging and Age-Related Disease Research Glutathione decline with aging makes it relevant for gerontology research: Age-Related GSH Decline: Investigation of mechanisms underlying tissue GSH depletion during aging Oxidative Stress Theory of Aging: Studies examining GSH status and aging-related oxidative damage accumulation Mitochondrial Aging: Research on mitochondrial GSH decline and bioenergetic dysfunction Senescence Research: Investigation of GSH levels in cellular senescence and senescence-associated secretory phenotype Age-Related Macular Degeneration: Studies on retinal GSH and oxidative damage in AMD models Cardiovascular Aging: Research on vascular GSH status and endothelial dysfunction with aging Sarcopenia Studies: Investigation of muscle GSH levels and age-related muscle loss Longevity Research: Examination of GSH status in long-lived species and lifespan extension interventions Experimental models include aged animal studies, accelerated aging models, cellular senescence systems, and comparative longevity research