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Does Smoking Cause Blood Clots? Understand the Risks Smoking is a Major DVT Risk Factor: Here's What You Should Know: Kishore K. Arcot , MD, FACC, FSCAI, FSVM, RPVI: Cardiology When we think about smoking, we usually think about lungs but it also affects your blood. Smoking makes your blood thicker and harder on your veins, raising your risk for a Smoking is the leading cause of heart disease. Every puff raises your blood pressure, damages your blood vessels, and increases the risk of a heart attack. Quit smoking today

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