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Ramifications of Thiamine Deficiency Department of Natural Resources, Cornell University, 2017

The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

Additionally, zinc functions as a signaling molecule, acting as a first or second messenger to regulate diverse signaling pathways, including NFB activation, apoptosis, and ion-channel activity (1316)