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The results from SILAC-based proteomic quantification revealed that under high glucose conditions, most K l-la modified peptides exhibited an increase, while most K d-la and K ce modified peptides showed no apparent alteration compared to low glucose conditions (Extended Data Fig

Interestingly, SLC38A1 and SLC38A2 protein is stored in intracellular vesicles from where it is rapidly transferred to the cell surface (103)

Reducing the function of TET3 through hypermethylation, however, could be also potentially involved in the development of AML alongside TET2 mutations [80]

Samples were vortexed, mixed with 165 L of 100 mM TEAB in 90% methanol, and passed through an S-Trap micro column at 4000 g for 30 s to trap the proteins