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While the exact reasons for these findings are unclear, chronic disease is often accompanied by increased resistance to finely adjusted regulatory pathways (e.g., treatment-resistant hypertension in kidney disease, insulin-resistance in metabolic syndrome) [28]

Notably, a disproportionate prevalence of obesity-related diseases is experienced by AI people in the U.S

References Ventura L, Arrizza L, Quaresima R, Capulli M (2022) Multidisciplinary investigation of an ancient renal stone in a mummy from Popoli, central Italy

TCF12 regulates the TGF-/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4