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This includes coordinated effects on both innate and adaptive responses and is mediated by engagement of key inflammatory and antioxidant signaling pathways (Figure 3)

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For additional information, we referred readers to our discussion of these issues in the CY 2012 PFS final rule with comment period (76 FR 73182) and the CY 2015 PFS final rule with comment period (79 FR 67639)

In particular, unimolecular decomposition of selected biomolecular precursor ions affords second- or higher-generation fragments in the mass spectrometer: this is the array of techniques referred to as tandem mass spectrometry or MS-MS [99]