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A Cochrane systematic review of the evidence concludes that there is high certainty evidence that vapes that contain nicotine increase long-term quit rates to a greater extent than Nicotine Replacement Therapy (NRT).[4] Furthermore, there is high certainty evidence that nicotine e-cigarettes, varenicline and cytisine are the stop-smoking aids most likely to help people quit smoking.[5] Varenicline and cytisine are only available on prescription and were used in less than 1% of quit attempts in 2022.[6] Vaping behaviour in never smokers About one in 70 adults who have never smoked currently vape (1.5%, Figure 5)