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Evidencia (sorafenib): En un estudio de aleatorizado de fase III, con enmascaramiento doble y controlado con placebo (DECISION [NCT00984282]), se evalu el sorafenib en pacientes de cncer de tiroides diferenciado y progresivo resistente a la terapia con yodo.[21] En este ensayo se incluyeron 417 pacientes con cncer de tiroides localmente avanzado o metastsico resistente a la terapia con YRA en los que la enfermedad haba progresado durante los 14 meses previos

Some 20 years later, my group of investigators at the VA hospital and Tulane University School of Medicine in New Orleans purified porcine hypothalamic LH-RH, which unequivocally stimulated the secretion of LH and FSH in men and women in studies at the National Institutes of Nutrition in Mexico City 2

Its specific regulatory mechanism is shown in Figure 1