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What they found: No serious adverse events triggered by AOD-9604 The most frequent side effects: headache (~5 %), occasional fatigue, at the same frequency as placebo No changes in IGF-1 levels, glycemia, blood pressure, heart rate No signals of cardiovascular, hepatic or renal toxicity Safety profile comparable to placebo Why it matters: From a safety perspective, AOD-9604 is one of the safest peptides in the clinical registry

The amide group in glutamine's side chain makes it both polar and hydrophilic

Through rational medicinal chemistry approaches, the development of inhibitors with high affinity and selectivity against ASCT2 is possible

Psychiatry 115 , 10251026 (1959)