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Conversely, no differences in lung function or histopathological changes were observed following exposure to e-cigarette aerosol, and less lung inflammation was observed in Apoe-/- mice [34, 35]

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Although sGC activator therapy has been shown to be efficacious in our model and in a broad variety of other preclinical disease models, human trials with the sGC activator were halted early because of systemic hypotension (43)