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Firstly, the synthesis of GSH-depleted multicomponent nanomedicines is so time-consuming that it still faces a huge technological gap from laboratory preparation to industrial production (Klochkov et al., 2021)

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Research models cover traumatic brain injury, hippocampal ischemia, cuprizone-induced demyelination (a multiple sclerosis model), and spinal cord compression injury with tail paralysis

From our results, we observed that GHK-Cu exhibits low potential of inducing skin irritation response in comparison with CuCl 2 and Cu(OAc) 2