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Initially, serum factors that were thought to be a modified TSH molecule and produced exophthalmos in experimental animal models were given the eponym exophthalmos producing substance (2, 3)

BOETTNER, E.A

It was also shown that the transformation of lettuce and tobacco by constitutive expression of the rat cDNA encoding L-gulono-1,4-lactone oxidase resulted in a four- to seven-fold increase in the content of vitamin C in the leaves of these plants [291]

217 In another study, the deubiquitinating enzyme OTUD1 inhibited the NF-B pathway by interacting with RIPK1 and inhibited the excessive production of the proinflammatory cytokines TNF-, IL-6, and IL-1 in UC, thereby inhibiting colon inflammation