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(2016) 14:160211.e5

In this study, the two ferroptosis-inhibiting factors, including GPX4 and FTH1, were significantly elevated in the chronic tophi, while the expression of the ferroptosis-promoting factor ALOX15 in acute joint cavity effusion was significantly higher than in chronic tophi

These insights underscore the need for combinatorial therapies that integrate epigenetic modulation, pathway inhibition, and apoptotic sensitization to overcome adaptive resistance (Tables 3 and 4) [160]