Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Product Name 2-Chloro-1-(methoxy-d3)-3-nitrobenzene Synonyms CAS

Product Name 2-Chloro-1-(methoxy-d3)-3-nitrobenzene Synonyms CAS Number n/a Related CAS Molecular Formula C7H6ClNO3 Molecular Weight 190

662 Purity (HPLC) >= 95% Solubility DMSO

87 SMILES: NCCCCCNS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Product Name 2-Chloro-1-(methoxy-d3)-3-nitrobenzene Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly