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The activity of NADPH oxidase (Nicotinamide adenine dinucleotide phosphate oxidase, NOX) is upregulated in the aorta, kidney, and adipose tissues in high fat diet-fed rats, leading to excessive production of superoxide ions a major oxygen free radical (129)

This inhibitor substantially decreased the number of cells in adherent and spheroid cultures as well, nevertheless it has increased their tumorigenic potential as determined by higher frequency of tumor-initiating cells in vivo

Kuopio birth cohort design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child