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10.1038/nrc1912 Nat

Phase 2 documented a clear dose-response: 9.1% at 2.4 mg versus 10.8% at 4.5 mg at 26 weeks (Lau et al., 2021)

Central to this ability are the many ways in which NF-B signaling is modulated based on shifting thresholds of activation, the integration of information from various classes of PRR, and tight regulation of transcription through rigorous positive and negative feedback loops