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The animals were then deeply anesthetized with 3% isoflurane and 50 mg/kg of ketamine followed by a laminectomy at lumbar level L2-L3, corresponding to the sacrocaudal spinal cord

Thus, we hypothesized that individual cell states depend on highly specialized metabolic programs at the mitochondrial level which could reveal novel state-specific druggable vulnerabilities

However, ellagic acid also has direct anti-androgenic effects by restricting 5-reductase, decreasing circulating testosterone levels

That includes certain antibiotics and powerful acid-suppressing drugs as well as the oral diabetes medication metformin