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The gene ribR encodes a monofunctional flavokinase as a part of the transcription unit consisting of 12 genes, whose products are involved in sulfur uptake and degradation

3.3 Soluble uric acids organ-specific effects on metabolic dysfunction 3.3.1 Soluble uric acid-induced endothelial dysfunction and cardiovascular remodeling ( Figure 3 ) Figure 3 Persistently elevated SUA in the heart can act as a damage-associated molecular pattern under pathological conditions, recognized by Toll-like receptors (such as TLR4) on the surface of cardiomyocytes and immune cells

In: Ulloa-Aguirre A, Tao Y-X, editors

Xie S, Fan W, He H, Huang F (2020) Role of melatonin in the regulation of pain