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Implications for management and future directions The reclassification from variants of uncertain significance to either pathogenic or likely pathogenic in accordance with ACMG guidelines, establishing a definitive diagnosis for an individual, is important for appropriate management, predictive testing for other family members, and the availability of reproductive options such as preimplantation genetic diagnosis (PGD)

Levels of serum suPAR also increase with COVID-19 severity (152) and is a predictive indicator of in-hospital AKI and the need for dialysis (153)

doi:10.1196/annals.1320.002