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In this group, supplementation is linked to promoting metabolic balance, particularly glycemia, insulin control and sensitivity, and effects on blood lipid concentrations [35, 44]

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J Biol Chem 277:2962629633 Murphy MP (2009) How mitochondria produce reactive oxygen species

Rational combinations, such as Ag or Cu for rapid load reduction, Zn for osteo-immunomodulation, and Ga for anti-biofilm pressure via iron mimicry, offer a coherent, non-antibiotic pathway to reduce implant-associated biofilm infections while restoring immune homeostasis Gas controlled-release antibacterial coatings Gasotransmitters such as nitric oxide (NO), hydrogen sulfide (HS), and carbon monoxide (CO) have recently emerged as promising non-antibiotic agents for combating implant-associated infections due to their dual antibacterial and immunomodulatory effects