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(59) demonstrated that tramadol increased glucose utilization via direct activation of MTOR in isolated hepatocytes and skeletal muscles of streptozotocin-induced diabetic rats

It's these initiation factors that can stay elevated for hours

169 Juglones specific cellular alkylation/arylation protein targets have been less intensively investigated in plants than in mammalian systems (see Pharmacology section below), but a number of potential targets can be postulated from the literature