Ultimately, as with any new supplement, its wise to talk to your doctor before incorporating creatine into your daily life
Periyasamy, Water, 2023, 15, 2532 CrossRef CAS

Including: Crocin biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis 68 map00280 Valine, leucine and isoleucine degradation 67 map00071 Fatty acid degradation 67 map00511 Other glycan degradation 67 map00970 Aminoacyl-tRNA biosynthesis 66 map00360 Phenylalanine metabolism 62 map00640 Propanoate metabolism 61 map00910 Nitrogen metabolism 60 map00220 Arginine biosynthesis 60 map00900 Terpenoid backbone biosynthesis 60 map00195 Photosynthesis 58 map00740 Riboflavin metabolism 58 map00600 Sphingolipid metabolism 58 map00946 Degradation of flavonoids 57 map00770 Pantothenate and CoA biosynthesis 55 map00310 Lysine degradation 54 map00330 Arginine and proline metabolism 54 map00510 N-Glycan biosynthesis 52 map00592 alpha-Linolenic acid metabolism 49 map00541 O-Antigen nucleotide sugar biosynthesis 45 map00760 Nicotinate and nicotinamide metabolism 45 map00650 Butanoate metabolism 45 map00062 Fatty acid elongation 44 map00340 Histidine metabolism 41 map00920 Sulfur metabolism 39 map00450 Selenocompound metabolism 37 map00790 Folate biosynthesis 36 map00531 Glycosaminoglycan degradation 36 map00140 Steroid hormone biosynthesis 35 map00670 One carbon pool by folate 34 map00565 Ether lipid metabolism 33 map00830 Retinol metabolism 32 map00950 Isoquinoline alkaloid biosynthesis 31 map00625 Chloroalkane and chloroalkene degradation 30 map00960 Tropane, piperidine and pyridine alkaloid biosynthesis 30 map00604 Glycosphingolipid biosynthesis - ganglio series 30 map00521 Streptomycin biosynthesis 27 map00073 Cutin, suberine and wax biosynthesis 25 map00941 Flavonoid biosynthesis 24 map00903 Limonene and pinene degradation 23 map00780 Biotin metabolism 23 map00513 Various types of N-glycan biosynthesis 23 map00290 Valine, leucine and isoleucine biosynthesis 22 map00100 Steroid biosynthesis 22 map00281 Geraniol degradation 20 map00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis 19 map00362 Benzoate degradation 18 map00981 Insect hormone biosynthesis 17 map00470 D-Amino acid metabolism 17 map00906 Carotenoid biosynthesis 17 map00909 Sesquiterpenoid and triterpenoid biosynthesis 16 map00300 Lysine biosynthesis 16 map00540 Lipopolysaccharide biosynthesis 15 map00524 Neomycin, kanamycin and gentamicin biosynthesis 15 map00401 Novobiocin biosynthesis 14 map00908 Zeatin biosynthesis 14 map00984 Steroid degradation 13 map00261 Monobactam biosynthesis 13 map00626 Naphthalene degradation 12 map00603 Glycosphingolipid biosynthesis - globo and isoglobo series 12 map00901 Indole alkaloid biosynthesis 12 map00998 Biosynthesis of various antibiotics

Once it exceeds 8 degrees Celsius, the degradation rate increases, though not catastrophically at first