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While vitamin B 12 deficiency is not a primary test in newborn screening programs, a study showed that markers C3, C3/C2, and C3/C16 exhibit a negative correlation with maternal levels of vitamin B 12 in the first trimester of pregnancy, and thus may bear diagnostic value (Dayaldasani et al., 12 insufficiency or deficiency during the first trimester of pregnancy and adequate treatment

Notably, carriers of the A allele in rs2107595 were associated with stroke mechanisms of in situ thrombo-occlusion and artery-to-artery embolism whereas carriers of the G allele with perforating artery occlusion

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