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Although there are several case reports of such an association,1316 a greater incidence of JMML has not been observed in larger series of patients with NF1 who presented with JXGs, including our series.4,5,7 Therefore, the suspicion of JMML in a patient with NF1 who develops JXGs should be directed by clinical symptoms and physical exploration, and not by the mere finding itself.11 Glomus Tumors The association of NF1 with glomus tumors was suspected since 1938,17 but it was not until 2009 when this association was definitively confirmed when NF1 mutations on both alleles was demonstrated in glomus cells.18 Glomus tumors are benign vascular lesions that originate in the glomus body, a neuro-myo-arterial structure specialized in the regulation of vascular flow

After lipid peroxidation occurs, the initiated generation of lipid hydroperoxides (LOOH) and subsequent generation of malondialdehyde (MDA) and 4-hydroxynonenal (4HNE) increase during ferroptosis, leading to a sustained oxidative stress response [67, 68]

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This selective neuronal mitochondrial targeting by SARS-CoV-2 may be an evolutionary advantage, as it causes brain fog and behavioral changes that favor viral propagation (29, 76)