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Huang WL, Wu FL, Huang HY, Huang WT, Deng CL, Yang LT, Huang ZR, Chen LS (2020) Excess copper-induced alterations of protein profiles and related physiological parameters in citrus leaves

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39 It is important to note that CYP2D6 polymorphisms only explain interpatient variability of metabolite concentrations to a limited extent, suggesting that other key factors impact the metabolism of tamoxifen, including factors influencing the subsequent metabolism of 4HT and endoxifen by uridine glucuronosyltransferase and sulfotransferase 1A (see Figure 1)