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Perspective Despite the recent regulatory successes and some remarkable scientific progress, ADC discovery and development still remains far from satisfactory and has many disappointing clinical results

doi: 10.1016/j.envpol.2020.114129 111 MesnageRTeixeiraMMandrioliDFalcioniLDucarmonQRZwittinkRDet al

26 Although ammonia concentrations are higher as the degree of encephalopathy worsens, significant overlap between concentrations is seen in different stages of encephalopathy, and about 70% of those with cirrhosis without encephalopathy have elevated ammonia concentrations