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They are both particularly susceptible to oxidative stress due to the high percentage of oxygen required for healthy brain function

The NIH literature on insulin-like growth factor 1 covers the IGF-1 biology underlying these endpoints

The research group led by Kojima and Kangawa was inspired by the fact that motilin, the endogenous ligand for GPR38 (the motilin receptor), which shares high amino acid homology with GHS-R1a, is secreted from the gastrointestinal tract