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Microglial activation was also seen in close proximity to vessels and stalled t-BHP-treated RBCs (Zhang et al., 2023)

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To bridge this gap, future studies should: (1) develop cell-specific metabolic interventions, (2) integrate metabolomics with single-cell and spatial omics to stratify patients by metabolic phenotype, and (3) conduct prospective clinical trials assessing safety, efficacy, and biomarker-guided treatment responses