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In contrast, HepG2 ATP7B-KO cells exhibited significant, dose-dependent upregulation of all six genes after 6 h, with sustained expression of GABARALP1 , PRAGC , and LAMTOR3 at 24 h

It was found that m6A modification-associated protein (IGF2BP3), which is highly expressed in human cervical cancer, can enhance Gln metabolism, promote lactate production and secretion, and affect Treg cell differentiation by up-regulating GLS and GLUD1, thus leading to immune escape [96]

Due to the limited research on human subjects, the range of possible side effects is not fully understood