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[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

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Fillers add volume or reshape facial features, while skin boosters improve overall skin quality without altering facial structure

Current evidence is not sufficient to support clinical use beyond research or investigational settings