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But we know it affects the amygdala

IL-1 and TNF- inhibit GABAergic neurons in the VLPO, reducing their inhibitory tone on wake-promoting regions such as the locus coeruleus and orexinergic hypothalamic neurons

Indian Journal of Dermatology, 54(4), 303-309

67 Proteaseanti-proteases imbalance during airway inflammation and airflow restriction may be an important factor affecting airway remodelling and airflow restriction